Reactome | Activated FGFR4 binds FRS2

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Activated FGFR4 binds FRS2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10614929
displayName	Activated FGFR4 binds FRS2
eventOf	[Pathway:R-DRE-5654712] FRS-mediated FGFR4 signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5654418] Activated FGFR4 phosphorylates FRS2 - Danio rerio
inferredFrom	[Reaction:R-HSA-5654422] Activated FGFR4 binds FRS2 - Homo sapiens
input	[DefinedSet:R-DRE-5654158] Activated FGFR4 [plasma membrane] [EntityWithAccessionedSequence:R-DRE-170963] frs2b [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR4 binds FRS2
output	[Complex:R-DRE-5654182] Activated FGFR4:FRS2 [plasma membrane]
precedingEvent	[Reaction:R-DRE-190326] Autocatalytic phosphorylation of FGFR4 - Danio rerio [Reaction:R-DRE-1307963] Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5654422
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5654712] FRS-mediated FGFR4 signaling
(precedingEvent)	[Reaction:R-DRE-5654418] Activated FGFR4 phosphorylates FRS2
(inferredTo)	[Reaction:R-HSA-5654422] Activated FGFR4 binds FRS2