Reactome | NUMB:ITCH binds GLI1

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10614241
displayName	NUMB:ITCH binds GLI1
eventOf	[Pathway:R-DRE-5632684] Hedgehog 'on' state - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5635864] NUMB:ITCH ubiquitinates GLI1 - Danio rerio
inferredFrom	[Reaction:R-HSA-5635861] NUMB:ITCH binds GLI1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-445457] gli1 [cytosol] [Complex:R-DRE-5610562] NUMB:ITCH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NUMB:ITCH binds GLI1
output	[Complex:R-DRE-5635832] GLI1:NUMB:ITCH [cytosol]
precedingEvent	[Reaction:R-DRE-5610735] NUMB binds ITCH - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5635861
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-5632684] Hedgehog 'on' state
(precedingEvent)	[Reaction:R-DRE-5635864] NUMB:ITCH ubiquitinates GLI1
(inferredTo)	[Reaction:R-HSA-5635861] NUMB:ITCH binds GLI1

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