Reactome | RAC1,CDC42:GTP:IQGAPs [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DRE-5626510] RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane] - Danio rerio
consumedByEvent	[Reaction:R-DRE-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10613884
displayName	RAC1,CDC42:GTP:IQGAPs [plasma membrane]
hasComponent	[DefinedSet:R-DRE-389778] CDC42:GTP, RAC1:GTP [plasma membrane] [DefinedSet:R-DRE-5626373] IQGAP [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5626465] RAC1,CDC42:GTP:IQGAPs [plasma membrane] - Homo sapiens
maxDepth	4
name	RAC1,CDC42:GTP:IQGAPs
negativelyRegulates	[NegativeRegulation:10615990] Negative regulation by 'RAC1,CDC42:GTP:IQGAPs [plasma membrane]'
producedByEvent	[Reaction:R-DRE-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-5626465
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(regulator)	[NegativeRegulation:10615990] Negative regulation by 'RAC1,CDC42:GTP:IQGAPs [plasma membrane]'
(input)	[Reaction:R-DRE-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin
(hasComponent)	[Complex:R-DRE-5626510] RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane]
(output)	[Reaction:R-DRE-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs
(inferredTo)	[Complex:R-HSA-5626465] RAC1,CDC42:GTP:IQGAPs [plasma membrane]

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