Reactome | RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3

Schema > Reaction > Entries

RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10613627
displayName	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
eventOf	[Pathway:R-DRE-5625740] RHO GTPases activate PKNs - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5623667] PDPK1 phosphorylates PKN1,2,3 - Danio rerio
inferredFrom	[Reaction:R-HSA-5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 - Homo sapiens
input	[Complex:R-DRE-109697] PDPK1:PIP3 [plasma membrane] [Complex:R-DRE-5623624] RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
output	[Complex:R-DRE-5623637] RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-DRE-5623622] RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 - Danio rerio [Reaction:R-DRE-8848618] Activation of RAC1 by the PXN:CRK complex - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5623632
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5625740] RHO GTPases activate PKNs
(precedingEvent)	[Reaction:R-DRE-5623667] PDPK1 phosphorylates PKN1,2,3
(inferredTo)	[Reaction:R-HSA-5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3

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