Reactome | ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

Schema > Reaction > Entries

ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10588529] fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10588531
displayName	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA
eventOf	[Pathway:R-DRE-75876] Synthesis of very long-chain fatty acyl-CoAs - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-548819] AA-CoA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29508] Mal-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH
output	[SimpleEntity:R-ALL-548816] 3ODCT-CoA [cytosol] [SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[Reaction:R-DRE-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-548800
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-75876] Synthesis of very long-chain fatty acyl-CoAs
(inferredTo)	[Reaction:R-HSA-548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

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