Reactome | DNA polymerase delta polymerizes DNA across single stranded gap

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DNA polymerase delta polymerizes DNA across single stranded gap Show undefined attributes

catalystActivity	[CatalystActivity:10560624] DNA-directed DNA polymerase activity of DNA Polymerase delta tetramer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10611995
displayName	DNA polymerase delta polymerizes DNA across single stranded gap
eventOf	[Pathway:R-DRE-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) - Danio rerio [Pathway:R-DRE-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Danio rerio
inferredFrom	[Reaction:R-HSA-5358579] DNA polymerase delta polymerizes DNA across single stranded gap - Homo sapiens
input	[SimpleEntity:R-ALL-29604] dATP [nucleoplasm] [SimpleEntity:R-ALL-30185] dCTP [nucleoplasm] [SimpleEntity:R-ALL-29892] dGTP [nucleoplasm] [SimpleEntity:R-ALL-30187] dTTP [nucleoplasm] [Complex:R-DRE-5358538] RPA:DNA containing single strand gap [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	DNA polymerase delta polymerizes DNA across single stranded gap
output	[OtherEntity:R-ALL-5358610] DNA containing single strand nick (5' phosphate, 3' hydroxyl) [nucleoplasm] [Complex:R-DRE-68462] RPA heterotrimer [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-DRE-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5358579
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) [Pathway:R-DRE-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
(precedingEvent)	[Reaction:R-DRE-5358592] DNA ligase I ligates single stranded nick in double stranded DNA
(inferredTo)	[Reaction:R-HSA-5358579] DNA polymerase delta polymerizes DNA across single stranded gap