Reactome | ROCK1,ROCK2 are activated

Schema > Reaction > Entries

category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10610815
displayName	ROCK1,ROCK2 are activated
eventOf	[Pathway:R-DRE-4420097] VEGFA-VEGFR2 Pathway - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5228992] ROCK1,ROCK2 are activated - Homo sapiens
input	[Complex:R-DRE-3928564] RHOA:GTP:ROCK1,ROCK2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ROCK1,ROCK2 are activated
output	[Complex:R-DRE-5228987] RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol]
precedingEvent	[Reaction:R-DRE-3928651] NGEF exchanges GTP for GDP on RHOA - Danio rerio [Reaction:R-DRE-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5228992
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-4420097] VEGFA-VEGFR2 Pathway
(inferredTo)	[Reaction:R-HSA-5228992] ROCK1,ROCK2 are activated

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