Reactome | ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)

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ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) Show undefined attributes

catalystActivity	[CatalystActivity:10610763] ABC-type vitamin B12 transporter activity of ABCD4:LMBRD1 [lysosomal membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10610765
displayName	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)
eventOf	[Pathway:R-DRE-9758881] Uptake of dietary cobalamins into enterocytes - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-3095901] ABCC1 transports cytosolic RCbl to extracellular region - Danio rerio
inferredFrom	[Reaction:R-HSA-5223313] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-9759390] RCbl [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) an R-cob(III)alamin(out) + ATP + H2O => ADP + an R-cob(III)alamin(in) + H(+) + phosphate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-9759394] RCbl [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5223313
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9758881] Uptake of dietary cobalamins into enterocytes
(precedingEvent)	[Reaction:R-DRE-3095901] ABCC1 transports cytosolic RCbl to extracellular region
(inferredTo)	[Reaction:R-HSA-5223313] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)

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