Reactome | N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10609389] ubiquitin protein ligase activity of N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-DRE-4641253] ZNRF3 ubiquitinates FZD to promote its downregulation - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10609384
displayName	N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane]
hasComponent	[DefinedSet:R-DRE-4641179-3] Homologues of ZNRF3 [plasma membrane] [Complex:R-DRE-4641176] N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-4641177] N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] - Homo sapiens
maxDepth	4
name	N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43
producedByEvent	[Reaction:R-DRE-4641249] ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-4641177
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DRE-4641253] ZNRF3 ubiquitinates FZD to promote its downregulation
(physicalEntity)	[CatalystActivity:10609389] ubiquitin protein ligase activity of N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane]
(output)	[Reaction:R-DRE-4641249] ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex
(inferredTo)	[Complex:R-HSA-4641177] N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane]

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