Reactome | NEDD8-AcM-UBE2M [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DRE-8952578] NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] - Danio rerio [Complex:R-DRE-8955949] NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol] - Danio rerio
consumedByEvent	[Reaction:R-DRE-8952620] NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952630] NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-4332236] CBL neddylates TGFBR2 - Danio rerio [Reaction:R-DRE-4332236] CBL neddylates TGFBR2 - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10608822
displayName	NEDD8-AcM-UBE2M [cytosol]
hasComponent	[DefinedSet:R-DRE-4419895-3] Homologues of C111-AcM-UBE2M-G76-NEDD8 [cytosol] [EntityWithAccessionedSequence:R-DRE-4419894] si:ch1073-205c8.4 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-4419896] NEDD8-AcM-UBE2M [cytosol] - Homo sapiens
maxDepth	3
name	NEDD8-AcM-UBE2M
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-4419896
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DRE-8952620] NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex [Reaction:R-DRE-8952630] NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex [Reaction:R-DRE-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex [Reaction:R-DRE-4332236] CBL neddylates TGFBR2
(hasComponent)	[Complex:R-DRE-8955949] NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol] [Complex:R-DRE-8952578] NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] [Complex:R-DRE-8952574] NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] [Complex:R-DRE-8952572] NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol]
(inferredTo)	[Complex:R-HSA-4419896] NEDD8-AcM-UBE2M [cytosol]

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