Reactome | Incretin synthesis, secretion, and inactivation

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Incretin synthesis, secretion, and inactivation Show undefined attributes

compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen [Compartment:1462052] secretory granule lumen [Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648942
displayName	Incretin synthesis, secretion, and inactivation
eventOf	[Pathway:R-DRE-2980736] Peptide hormone metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19561] peptide hormone processing
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DRE-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Danio rerio [Pathway:R-DRE-400511] Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) - Danio rerio
inferredFrom	[Pathway:R-HSA-400508] Incretin synthesis, secretion, and inactivation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Incretin synthesis, secretion, and inactivation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-400508
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2980736] Peptide hormone metabolism
(inferredTo)	[Pathway:R-HSA-400508] Incretin synthesis, secretion, and inactivation

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