Reactome | KALRN exchanges GTP for GDP on RAC1, activating it

Schema > Reaction > Entries

KALRN exchanges GTP for GDP on RAC1, activating it Show undefined attributes

catalystActivity	[CatalystActivity:10608227] guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:KALRN [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10608229
displayName	KALRN exchanges GTP for GDP on RAC1, activating it
eventOf	[Pathway:R-DRE-3928662] EPHB-mediated forward signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3928612] KALRN exchanges GTP for GDP on RAC1, activating it - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-DRE-217287] RAC1:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	KALRN exchanges GTP for GDP on RAC1, activating it
output	[SimpleEntity:R-ALL-114549] GDP [plasma membrane] [Complex:R-DRE-217289] RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-DRE-3928617] EPHB2 binds KALRN - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-3928612
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-3928662] EPHB-mediated forward signaling
(inferredTo)	[Reaction:R-HSA-3928612] KALRN exchanges GTP for GDP on RAC1, activating it

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