Reactome | HAO1 tetramer oxidizes glycolate to glyoxylate

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HAO1 tetramer oxidizes glycolate to glyoxylate Show undefined attributes

catalystActivity	[CatalystActivity:10582603] (S)-2-hydroxy-acid oxidase activity of HAO1 tetramer [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10582605
displayName	HAO1 tetramer oxidizes glycolate to glyoxylate
eventOf	[Pathway:R-DRE-389661] Glyoxylate metabolism and glycine degradation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-389862] Conversion of glyoxylate to oxalate - Danio rerio [Reaction:R-DRE-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Danio rerio [Reaction:R-DRE-76031] 2 H2O2 => O2 + 2 H2O - Danio rerio
inferredFrom	[Reaction:R-HSA-389842] HAO1 tetramer oxidizes glycolate to glyoxylate - Homo sapiens
input	[SimpleEntity:R-ALL-389822] glycolate [peroxisomal matrix] [SimpleEntity:R-ALL-113535] O2 [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	HAO1 tetramer oxidizes glycolate to glyoxylate glycolate + O2 => glyoxylate + H2O2
output	[SimpleEntity:R-ALL-389678] glyoxylate [peroxisomal matrix] [SimpleEntity:R-ALL-113575] H2O2 [peroxisomal matrix]
precedingEvent	[Reaction:R-DRE-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-389842
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DRE-76031] 2 H2O2 => O2 + 2 H2O [Reaction:R-DRE-389862] Conversion of glyoxylate to oxalate [Reaction:R-DRE-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome]
(hasEvent)	[Pathway:R-DRE-389661] Glyoxylate metabolism and glycine degradation
(inferredTo)	[Reaction:R-HSA-389842] HAO1 tetramer oxidizes glycolate to glyoxylate

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