Reactome | HDAC1:2-containing complex deacetylate histones

Schema > Reaction > Entries

HDAC1:2-containing complex deacetylate histones Show undefined attributes

catalystActivity	[CatalystActivity:10607573] histone deacetylase activity of HDAC1:2-containing complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10607577
displayName	HDAC1:2-containing complex deacetylate histones
eventOf	[Pathway:R-DRE-3214815] HDACs deacetylate histones - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3769447] HDAC1:2-containing complex deacetylate histones - Homo sapiens
input	[Complex:R-DRE-4663858] Acetylated core histone octamer [nucleoplasm] 15 × [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	HDAC1:2-containing complex deacetylate histones
output	15 × [SimpleEntity:R-ALL-5566518] acetate [nucleoplasm] [Complex:R-DRE-4657034] Core histone octamer [nucleoplasm]
regulatedBy	[NegativeRegulation:10607578] Negative regulation by 'HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-3769447
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-3214815] HDACs deacetylate histones
(inferredTo)	[Reaction:R-HSA-3769447] HDAC1:2-containing complex deacetylate histones

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