Reactome | NCAM signaling for neurite out-growth

Schema > Pathway > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648652
displayName	NCAM signaling for neurite out-growth
eventOf	[Pathway:R-DRE-422475] Axon guidance - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Danio rerio [Reaction:R-DRE-198756] ERK1/2 phosphorylates MSK1 - Danio rerio [Reaction:R-DRE-199935] MSK1 activates CREB - Danio rerio
inferredFrom	[Pathway:R-HSA-375165] NCAM signaling for neurite out-growth - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	NCAM signaling for neurite out-growth
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-375165
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-422475] Axon guidance
(hasEncapsulatedEvent)	[Pathway:R-DRE-5673001] RAF/MAP kinase cascade
(inferredTo)	[Pathway:R-HSA-375165] NCAM signaling for neurite out-growth

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