Reactome | Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1

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Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 Show undefined attributes

catalystActivity	[CatalystActivity:10606684] alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity of oligoGlc-GYG1:GYS1-b tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10606686
displayName	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
eventOf	[Pathway:R-DRE-3322077] Glycogen synthesis - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-3322057] GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b - Danio rerio
inferredFrom	[Reaction:R-HSA-3322041] Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Homo sapiens
input	[Complex:R-DRE-3322053] oligoGlc-GYG1:GYS1-b tetramer [cytosol] 8 × [SimpleEntity:R-ALL-29410] UDP-Glc [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 ((1->4)-alpha-D-glucosyl)(n) + UDP-alpha-D-glucose => ((1->4)-alpha-D-glucosyl)(n+1) + UDP + H(+) 8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin (GYS1-b)
output	8 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [Complex:R-DRE-3322063] polyGlc-GYG1:GYS1-b tetramer [cytosol] 8 × [SimpleEntity:R-ALL-110096] UDP [cytosol]
precedingEvent	[Reaction:R-DRE-3322003] Autoglucosylation of GYG1 complexed with GYS1-b - Danio rerio
regulatedBy	[Requirement:R-HSA-3322037] Requirement by 'G6P [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-3322041
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-3322077] Glycogen synthesis
(precedingEvent)	[Reaction:R-DRE-3322057] GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b
(inferredTo)	[Reaction:R-HSA-3322041] Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1

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