Reactome | secretion of WNT ligands

Schema > Reaction > Entries

secretion of WNT ligands Show undefined attributes

category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10606156
displayName	secretion of WNT ligands
eventOf	[Pathway:R-DRE-3238698] WNT ligand biogenesis and trafficking - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DRE-3247847] WLS is endocytosed to the early endosome - Danio rerio [Reaction:R-DRE-5323545] Canonical WNT signaling through the atypical receptor RYK - Danio rerio [Reaction:R-DRE-5140741] WNT5A binds FZD and ROR receptors - Danio rerio [Reaction:R-DRE-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Danio rerio
inferredFrom	[Reaction:R-HSA-3247843] secretion of WNT ligands - Homo sapiens
input	[Complex:R-DRE-3247838] WLS:WNT [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	secretion of WNT ligands
output	[EntityWithAccessionedSequence:R-DRE-3247746] wls [plasma membrane] [DefinedSet:R-DRE-3247835] WNTs [extracellular region]
precedingEvent	[BlackBoxEvent:R-DRE-3247844] WNT ligands traffic to the plasma membrane - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-3247843
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-3238698] WNT ligand biogenesis and trafficking
(precedingEvent)	[BlackBoxEvent:R-DRE-3247847] WLS is endocytosed to the early endosome [Reaction:R-DRE-5323545] Canonical WNT signaling through the atypical receptor RYK [Reaction:R-DRE-5140741] WNT5A binds FZD and ROR receptors [Reaction:R-DRE-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation
(inferredTo)	[Reaction:R-HSA-3247843] secretion of WNT ligands