Reactome | BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1

Schema > Reaction > Entries

BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 Show undefined attributes

catalystActivity	[CatalystActivity:10578150] metalloendopeptidase activity of BMP1-3:Zn2+ [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10578152
displayName	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1
eventOf	[Pathway:R-DRE-8963896] HDL assembly - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-216727] 4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 - Danio rerio
inferredFrom	[Reaction:R-HSA-264758] BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-264771] apoa1a [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1
output	[EntityWithAccessionedSequence:R-DRE-174720] apoa1a [extracellular region]
regulatedBy	[NegativeRegulation:10578153] Negative regulation by 'A2M tetramer [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-264758
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-8963896] HDL assembly
(precedingEvent)	[Reaction:R-DRE-216727] 4xPALM-C-p-2S-ABCA1 tetramer binds APOA1
(inferredTo)	[Reaction:R-HSA-264758] BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1

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