Reactome | Deacetylation of cleaved cohesin

Schema > Reaction > Entries

Deacetylation of cleaved cohesin Show undefined attributes

catalystActivity	[CatalystActivity:10604567] histone deacetylase activity of HDAC8 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10604569
displayName	Deacetylation of cleaved cohesin
eventOf	[Pathway:R-DRE-2467813] Separation of Sister Chromatids - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2545203] Deacetylation of cleaved cohesin - Homo sapiens
input	[Complex:R-DRE-2467805] Cleaved Cohesin:PDS5:WAPAL [cytosol] 2 × [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [EntityWithAccessionedSequence:R-DRE-2484795] rad21b [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Deacetylation of cleaved cohesin
output	2 × [SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [Complex:R-DRE-2545214] Cohesin Complex [cytosol] [DefinedSet:R-DRE-2484796] PDS5 [cytosol] [EntityWithAccessionedSequence:R-DRE-2500309] phospho-rad21b [cytosol] [EntityWithAccessionedSequence:R-DRE-2484901] rad21b [cytosol] [EntityWithAccessionedSequence:R-DRE-2500308] rad21b [cytosol] [EntityWithAccessionedSequence:R-DRE-2484802] wapla [cytosol]
precedingEvent	[Reaction:R-DRE-2467811] Separation of sister chromatids - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-2545203
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2467813] Separation of Sister Chromatids
(inferredTo)	[Reaction:R-HSA-2545203] Deacetylation of cleaved cohesin