Reactome | Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor

Schema > BlackBoxEvent > Entries

Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor Show undefined attributes

category	omitted
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10602996
displayName	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
eventOf	[Pathway:R-DRE-2179392] EGFR Transactivation by Gastrin - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Danio rerio
inferredFrom	[BlackBoxEvent:R-HSA-2179387] Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-179837] EGFR [plasma membrane] [EntityWithAccessionedSequence:R-DRE-1233234] hbegfa [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
output	[Complex:R-DRE-2179410] HB-EGF:p-6Y-EGFR dimer [plasma membrane]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68323] Danio rerio
stId	R-DRE-2179387
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2179392] EGFR Transactivation by Gastrin
(precedingEvent)	[Reaction:R-DRE-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR
(inferredTo)	[BlackBoxEvent:R-HSA-2179387] Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor

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