Reactome | Arachidonate is oxidised to 12R-HpETE by ALOX12B

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Arachidonate is oxidised to 12R-HpETE by ALOX12B Show undefined attributes

catalystActivity	[CatalystActivity:10602705] arachidonate 12(S)-lipoxygenase activity of ALOX12B:Fe2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10602707
displayName	Arachidonate is oxidised to 12R-HpETE by ALOX12B
eventOf	[Pathway:R-DRE-2142712] Synthesis of 12-eicosatetraenoic acid derivatives - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-8942208] ALOXE3 isomerises 12R-HpETE to HXA3 - Danio rerio
inferredFrom	[Reaction:R-HSA-2161950] Arachidonate is oxidised to 12R-HpETE by ALOX12B - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Arachidonate is oxidised to 12R-HpETE by ALOX12B (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
output	[SimpleEntity:R-ALL-2142790] 12R-HpETE [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-2161950
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2142712] Synthesis of 12-eicosatetraenoic acid derivatives
(precedingEvent)	[Reaction:R-DRE-8942208] ALOXE3 isomerises 12R-HpETE to HXA3
(inferredTo)	[Reaction:R-HSA-2161950] Arachidonate is oxidised to 12R-HpETE by ALOX12B

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