Reactome | STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7

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STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10601095
displayName	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
eventOf	[Pathway:R-DRE-2173788] Downregulation of TGF-beta receptor signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2128994] STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-173478] smad7 [cytosol] [Complex:R-DRE-2127564] TGFB1:p-TGFBR:STRAP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
output	[Complex:R-DRE-2128993] TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-2128994
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2173788] Downregulation of TGF-beta receptor signaling
(inferredTo)	[Reaction:R-HSA-2128994] STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7

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