Reactome | Interaction of Tie2 and Ang4

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10576854
displayName	Interaction of Tie2 and Ang4
eventOf	[Pathway:R-DRE-210993] Tie2 Signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-204824] Interaction of Tie2 and Ang4 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-204867] angpt4 [extracellular region] [EntityWithAccessionedSequence:R-DRE-197755] TEK [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of Tie2 and Ang4
output	[Complex:R-DRE-204789] ANGPT4:TEK [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-204824
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-210993] Tie2 Signaling
(inferredTo)	[Reaction:R-HSA-204824] Interaction of Tie2 and Ang4

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