Reactome | Linoleic acid (LA) metabolism

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Linoleic acid (LA) metabolism Show undefined attributes

compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:17951] peroxisomal matrix [Compartment:17947] peroxisomal membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649636
displayName	Linoleic acid (LA) metabolism
eventOf	[Pathway:R-DRE-2046104] alpha-linolenic (omega3) and linoleic (omega6) acid metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262828] linoleic acid metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-2046098] Activation of linoleic acid to linoleoyl-CoA - Danio rerio [Reaction:R-DRE-2046096] Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA - Danio rerio [Reaction:R-DRE-2046094] Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA - Danio rerio [Reaction:R-DRE-2046083] Elongation of arachidonyl-CoA to docosatetraenoyl-CoA - Danio rerio [Reaction:R-DRE-2046095] Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA - Danio rerio [Reaction:R-DRE-2046097] Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA - Danio rerio [Reaction:R-DRE-2046093] Translocation of tetracosapentaenoyl-CoA to peroxisomes - Danio rerio
inferredFrom	[Pathway:R-HSA-2046105] Linoleic acid (LA) metabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Linoleic acid (LA) metabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-2046105
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2046104] alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
(inferredTo)	[Pathway:R-HSA-2046105] Linoleic acid (LA) metabolism