Reactome | Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA

Schema > Reaction > Entries

Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10600714] fatty acid elongase activity of ELOVL5/ELOVL2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10600750
displayName	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA
eventOf	[Pathway:R-DRE-2046106] alpha-linolenic acid (ALA) metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-2046090] Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA - Danio rerio
inferredFrom	[Reaction:R-HSA-2046100] Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-2046059] EPA-CoA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-2046066] Malonyl-CoA [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA
output	[SimpleEntity:R-ALL-159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-162743] CoA-SH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-2046057] DPA-CoA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-2046100
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2046106] alpha-linolenic acid (ALA) metabolism
(precedingEvent)	[Reaction:R-DRE-2046090] Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA
(inferredTo)	[Reaction:R-HSA-2046100] Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA

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