Reactome | Phosphorylation of YAP by LATS1

Schema > Reaction > Entries

Phosphorylation of YAP by LATS1 Show undefined attributes

catalystActivity	[CatalystActivity:10600493] protein serine/threonine kinase activity of p-LATS1:p-MOB1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10600495
displayName	Phosphorylation of YAP by LATS1
eventOf	[Pathway:R-DRE-2028269] Signaling by Hippo - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-2028644] YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 - Danio rerio
inferredFrom	[Reaction:R-HSA-2028598] Phosphorylation of YAP by LATS1 - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-DRE-1253345] yap1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of YAP by LATS1
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-DRE-2028554] phospho-yap1 [cytosol]
precedingEvent	[Reaction:R-DRE-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Danio rerio [Reaction:R-DRE-2028673] Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-2028598
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2028269] Signaling by Hippo
(precedingEvent)	[Reaction:R-DRE-2028644] YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1
(inferredTo)	[Reaction:R-HSA-2028598] Phosphorylation of YAP by LATS1

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