Reactome | NDST1-4 N-deacetylates GlcNAc residues in heparan

Schema > Reaction > Entries

NDST1-4 N-deacetylates GlcNAc residues in heparan Show undefined attributes

catalystActivity	[CatalystActivity:10600174] N-acetylglucosamine deacetylase activity of NDSTs [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10600176
displayName	NDST1-4 N-deacetylates GlcNAc residues in heparan
eventOf	[Pathway:R-DRE-2022928] HS-GAG biosynthesis - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) - Danio rerio
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
inferredFrom	[Reaction:R-HSA-2022887] NDST1-4 N-deacetylates GlcNAc residues in heparan - Homo sapiens
input	[SimpleEntity:R-ALL-2022884] H2O [Golgi lumen] [DefinedSet:R-DRE-2076535] Heparan(3)-PGs [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	NDST1-4 N-deacetylates GlcNAc residues in heparan
output	[SimpleEntity:R-ALL-2022890] CH3COO- [Golgi lumen] [DefinedSet:R-DRE-2076346] Heparan(4)-PGs [Golgi lumen]
precedingEvent	[Reaction:R-DRE-2076392] EXT1:EXT2 transfers GlcA to heparan - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-2022887
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2022928] HS-GAG biosynthesis
(precedingEvent)	[Reaction:R-DRE-2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
(inferredTo)	[Reaction:R-HSA-2022887] NDST1-4 N-deacetylates GlcNAc residues in heparan

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