Reactome | ERK5 translocates to the nucleus

Schema > Reaction > Entries

category	transition
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10574496
displayName	ERK5 translocates to the nucleus
eventOf	[Pathway:R-DRE-198765] Signalling to ERK5 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-198746] ERK1/2/5 activate RSK1/2/3 - Danio rerio
inferredFrom	[Reaction:R-HSA-198714] ERK5 translocates to the nucleus - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-198721] phospho-p-T218,Y221-MAPK7 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ERK5 translocates to the nucleus
output	[EntityWithAccessionedSequence:R-DRE-198738] phospho-p-T218,Y221-MAPK7 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-198714
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-198765] Signalling to ERK5
(precedingEvent)	[Reaction:R-DRE-198746] ERK1/2/5 activate RSK1/2/3
(inferredTo)	[Reaction:R-HSA-198714] ERK5 translocates to the nucleus

Cite Us!