Reactome | FPGS-2 transforms THF to THFPG

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FPGS-2 transforms THF to THFPG Show undefined attributes

catalystActivity	[CatalystActivity:10574332] tetrahydrofolylpolyglutamate synthase activity of FPGS-2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10574334
displayName	FPGS-2 transforms THF to THFPG
eventOf	[Pathway:R-DRE-196757] Metabolism of folate and pterines - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG - Danio rerio [Reaction:R-DRE-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Danio rerio
inferredFrom	[Reaction:R-HSA-197958] FPGS-2 transforms THF to THFPG - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] 5 × [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FPGS-2 transforms THF to THFPG Conversion of cytosolic THF to THF-polyglutamate
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 5 × [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-197969] THFPG [cytosol]
precedingEvent	[Reaction:R-DRE-197972] DHF is reduced to tetrahydrofolate (THF) - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-197958
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-DRE-200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG [Reaction:R-DRE-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG
(inferredTo)	[Reaction:R-HSA-197958] FPGS-2 transforms THF to THFPG

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