Reactome | Pregnenolone biosynthesis

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Pregnenolone biosynthesis Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648558
displayName	Pregnenolone biosynthesis
eventOf	[Pathway:R-DRE-196071] Metabolism of steroid hormones - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21389] C21-steroid hormone biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-196126] STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space - Danio rerio [Reaction:R-DRE-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Danio rerio [Reaction:R-DRE-193065] Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol - Danio rerio [Reaction:R-DRE-193101] CYP11A1 cleaves 20a,22b-DHCHOL - Danio rerio [Reaction:R-DRE-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Danio rerio
inferredFrom	[Pathway:R-HSA-196108] Pregnenolone biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Pregnenolone biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-196108
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-196071] Metabolism of steroid hormones
(inferredTo)	[Pathway:R-HSA-196108] Pregnenolone biosynthesis

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