Reactome | Homodimerization of VEGF proteins

Schema > Reaction > Entries

Homodimerization of VEGF proteins Show undefined attributes

category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10574087
displayName	Homodimerization of VEGF proteins
eventOf	[Pathway:R-DRE-194313] VEGF ligand-receptor interactions - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-194308] VEGF-C,D bind to VEGFR3 leading to receptor dimerization - Danio rerio [Reaction:R-DRE-194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - Danio rerio [Reaction:R-DRE-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Danio rerio
inferredFrom	[Reaction:R-HSA-195378] Homodimerization of VEGF proteins - Homo sapiens
input	2 × [DefinedSet:R-DRE-195361] VEGF [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Homodimerization of VEGF proteins
output	[DefinedSet:R-DRE-195376] VEGF dimer [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-195378
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-194313] VEGF ligand-receptor interactions
(precedingEvent)	[Reaction:R-DRE-194308] VEGF-C,D bind to VEGFR3 leading to receptor dimerization [Reaction:R-DRE-194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization [Reaction:R-DRE-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization
(inferredTo)	[Reaction:R-HSA-195378] Homodimerization of VEGF proteins