Reactome | CYP27A1 27-hydroxylates CHOL

Schema > Reaction > Entries

CYP27A1 27-hydroxylates CHOL Show undefined attributes

catalystActivity	[CatalystActivity:10573343] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10573379
displayName	CYP27A1 27-hydroxylates CHOL
eventOf	[Pathway:R-DRE-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Danio rerio [Pathway:R-DRE-211976] Endogenous sterols - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-192123] CYP27A1 27-hydroxylates CHOL - Homo sapiens
input	[SimpleEntity:R-ALL-193840] CHOL [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP27A1 27-hydroxylates CHOL cholesterol + NADPH + H+ + O2 => 27-hydroxycholesterol + H2O + NADP+
output	[SimpleEntity:R-ALL-193846] 27OH-CHOL [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-192123
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol [Pathway:R-DRE-211976] Endogenous sterols
(inferredTo)	[Reaction:R-HSA-192123] CYP27A1 27-hydroxylates CHOL

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