Reactome | UROS transforms HMB to URO3

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UROS transforms HMB to URO3 Show undefined attributes

catalystActivity	[CatalystActivity:10572925] uroporphyrinogen-III synthase activity of UROS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10572927
displayName	UROS transforms HMB to URO3
eventOf	[Pathway:R-DRE-189451] Heme biosynthesis - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-189425] UROD decarboxylates URO3 to COPRO3 - Danio rerio
inferredFrom	[Reaction:R-HSA-189488] UROS transforms HMB to URO3 - Homo sapiens
input	[SimpleEntity:R-ALL-189449] HMBL [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	UROS transforms HMB to URO3 hydroxymethylbilane => H2O + uroporphyrinogen III Conversion of HMB to uroporphyrinogen III
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-189407] URO3 [cytosol]
precedingEvent	[Reaction:R-DRE-189406] 4 PBGs bind to form HMB - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-189488
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-189451] Heme biosynthesis
(precedingEvent)	[Reaction:R-DRE-189425] UROD decarboxylates URO3 to COPRO3
(inferredTo)	[Reaction:R-HSA-189488] UROS transforms HMB to URO3

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