Reactome | Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[BlackBoxEvent:R-DRE-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10572683
displayName	Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm]
hasComponent	[Complex:R-DRE-187565] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] 3 × [DefinedSet:R-DRE-68524] Ub [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-187568] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] - Homo sapiens
maxDepth	7
name	Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin
producedByEvent	[Reaction:R-DRE-187575] Ubiquitination of phospho-p27/p21 - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-187568
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[BlackBoxEvent:R-DRE-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome
(output)	[Reaction:R-DRE-187575] Ubiquitination of phospho-p27/p21
(inferredTo)	[Complex:R-HSA-187568] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm]

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