Reactome | Phosphorylation of CBL (EGFR:GRB2:CBL)

Schema > Reaction > Entries

Phosphorylation of CBL (EGFR:GRB2:CBL) Show undefined attributes

catalystActivity	[CatalystActivity:10572504] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10572506
displayName	Phosphorylation of CBL (EGFR:GRB2:CBL)
eventOf	[Pathway:R-DRE-182971] EGFR downregulation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-183036] Ubiquitination of stimulated EGFR (CBL:GRB2) - Danio rerio
inferredFrom	[Reaction:R-HSA-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DRE-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of CBL (EGFR:GRB2:CBL)
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DRE-182948] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
precedingEvent	[Reaction:R-DRE-183067] Localization of CBL:GRB2 to the membrane - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-183058
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-182971] EGFR downregulation
(precedingEvent)	[Reaction:R-DRE-183036] Ubiquitination of stimulated EGFR (CBL:GRB2)
(inferredTo)	[Reaction:R-HSA-183058] Phosphorylation of CBL (EGFR:GRB2:CBL)

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