Reactome | The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere

Schema > Reaction > Entries

The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere Show undefined attributes

catalystActivity	[CatalystActivity:10571773] DNA-directed DNA polymerase activity of RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10571775
displayName	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
eventOf	[Pathway:R-DRE-174430] Telomere C-strand synthesis initiation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
inferredFrom	[Reaction:R-HSA-174427] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere - Homo sapiens
input	[SimpleEntity:R-ALL-29604] dATP [nucleoplasm] [SimpleEntity:R-ALL-30185] dCTP [nucleoplasm] [SimpleEntity:R-ALL-29892] dGTP [nucleoplasm] [SimpleEntity:R-ALL-30187] dTTP [nucleoplasm] [Complex:R-DRE-174434] RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
output	[Complex:R-DRE-174433] RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm]
precedingEvent	[Reaction:R-DRE-174425] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-174427
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-174430] Telomere C-strand synthesis initiation
(inferredTo)	[Reaction:R-HSA-174427] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere

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