Reactome | PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane

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PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane Show undefined attributes

catalystActivity	[CatalystActivity:10597500] phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTM1,MTMR2,MTMR4 [cytosol]
category	transition
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10597502
displayName	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane
eventOf	[Pathway:R-DRE-1660516] Synthesis of PIPs at the early endosome membrane - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1676105] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806205] PI(3,5)P2 [early endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806259] PI5P [early endosome membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1676105
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1660516] Synthesis of PIPs at the early endosome membrane
(inferredTo)	[Reaction:R-HSA-1676105] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane

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