Reactome | PKA activation

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PKA activation Show undefined attributes

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10647972
displayName	PKA activation
eventOf	[Pathway:R-DRE-111931] PKA-mediated phosphorylation of CREB - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:210811] activation of protein kinase A activity
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-111930] Adenylate cyclase produces cAMP - Danio rerio [Reaction:R-DRE-8951727] cAMP binds PKA tetramer - Danio rerio [Reaction:R-DRE-111925] cAMP induces dissociation of inactive PKA tetramers - Danio rerio
inferredFrom	[Pathway:R-HSA-163615] PKA activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PKA activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-163615
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-111931] PKA-mediated phosphorylation of CREB
(inferredTo)	[Pathway:R-HSA-163615] PKA activation