Reactome | PI is hydrolyzed to 1-acyl LPI by PLA2[11]

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PI is hydrolyzed to 1-acyl LPI by PLA2[11] Show undefined attributes

catalystActivity	[CatalystActivity:10596053] A2-type glycerophospholipase activity of PLA2(11) [cytosol]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10596055
displayName	PI is hydrolyzed to 1-acyl LPI by PLA2[11]
eventOf	[Pathway:R-DRE-1482922] Acyl chain remodelling of PI - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Danio rerio
inferredFrom	[Reaction:R-HSA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI is hydrolyzed to 1-acyl LPI by PLA2[11]
output	[SimpleEntity:R-ALL-1498733] 1-acyl LPI [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-DRE-1482976] CDP-DAG is converted to PI by CDIPT - Danio rerio [Reaction:R-DRE-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Danio rerio [Reaction:R-DRE-1482626] 2-acyl LPI is acylated to PI by MBOAT7 - Danio rerio [Reaction:R-DRE-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1482825
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1482922] Acyl chain remodelling of PI
(inferredTo)	[Reaction:R-HSA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11]
(precedingEvent)	[Reaction:R-DRE-1482598] 1-acyl LPI is acylated to PI by MBOAT7