Reactome | 2-MAG is transacylated to DAG by PNPLA2/3

Schema > Reaction > Entries

2-MAG is transacylated to DAG by PNPLA2/3 Show undefined attributes

catalystActivity	[CatalystActivity:10595986] acylglycerol O-acyltransferase activity of PNPLA2/3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10595990
displayName	2-MAG is transacylated to DAG by PNPLA2/3
eventOf	[Pathway:R-DRE-1482883] Acyl chain remodeling of DAG and TAG - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 - Danio rerio [Reaction:R-DRE-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Danio rerio [Reaction:R-DRE-1482889] DAG is acylated to TAG by DGAT1/2 - Danio rerio [Reaction:R-DRE-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 - Danio rerio [Reaction:R-DRE-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Danio rerio
inferredFrom	[Reaction:R-HSA-1482654] 2-MAG is transacylated to DAG by PNPLA2/3 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-1498728] 2-MAG [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	2-MAG is transacylated to DAG by PNPLA2/3
output	[SimpleEntity:R-ALL-1500596] DAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-76116] Glycerol [cytosol]
precedingEvent	[Reaction:R-DRE-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1482654
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1482883] Acyl chain remodeling of DAG and TAG
(precedingEvent)	[Reaction:R-DRE-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 [Reaction:R-DRE-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Reaction:R-DRE-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 [Reaction:R-DRE-1482889] DAG is acylated to TAG by DGAT1/2 [Reaction:R-DRE-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3
(inferredTo)	[Reaction:R-HSA-1482654] 2-MAG is transacylated to DAG by PNPLA2/3