Reactome | Inactivation of APC/C via direct inhibition of the APC/C complex

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Inactivation of APC/C via direct inhibition of the APC/C complex Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648094
displayName	Inactivation of APC/C via direct inhibition of the APC/C complex
eventOf	[Pathway:R-DRE-141405] Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-141437] Formation of the MCC complex - Danio rerio [Reaction:R-DRE-141423] Binding of the MCC complex to the APC/C complex - Danio rerio
inferredFrom	[Pathway:R-HSA-141430] Inactivation of APC/C via direct inhibition of the APC/C complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Inactivation of APC/C via direct inhibition of the APC/C complex
precedingEvent	[Reaction:R-DRE-141439] Release of activated MAD2 from kinetochores - Danio rerio
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-141430
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-141405] Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
(inferredTo)	[Pathway:R-HSA-141430] Inactivation of APC/C via direct inhibition of the APC/C complex

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