Reactome | factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides

Schema > Reaction > Entries

factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides Show undefined attributes

catalystActivity	[CatalystActivity:10567669] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10567925
displayName	factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
eventOf	[Pathway:R-DRE-9769733] Fibrin formation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-140847] factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain - Danio rerio
inferredFrom	[Reaction:R-HSA-140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides - Homo sapiens
input	[Complex:R-DRE-140608] factor XIII [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
output	2 × [EntityWithAccessionedSequence:R-DRE-140790] F13A1(1-37) [extracellular region] [Complex:R-DRE-140789] factor XIII cleaved tetramer [extracellular region]
precedingEvent	[Reaction:R-DRE-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Danio rerio
regulatedBy	[PositiveRegulation:10567926] Positive regulation by 'fibrin multimer [extracellular region]' [NegativeRegulation:10567927] Negative regulation by 'Extracellular thrombin inactivating complexes [extracellular region]' [NegativeRegulation:10567928] Negative regulation by 'SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane]' [NegativeRegulation:10567929] Negative regulation by 'Factor IIa inhibitors:IIa [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-140599
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9769733] Fibrin formation
(precedingEvent)	[Reaction:R-DRE-140847] factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain
(inferredTo)	[Reaction:R-HSA-140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides

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