Reactome | PI3K events in ERBB4 signaling

Schema > Pathway > Entries

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649418
displayName	PI3K events in ERBB4 signaling
eventOf	[Pathway:R-DRE-1236394] Signaling by ERBB4 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-1250353] Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers - Danio rerio [Reaction:R-DRE-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Danio rerio
inferredFrom	[Pathway:R-HSA-1250342] PI3K events in ERBB4 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PI3K events in ERBB4 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-1250342
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-1236394] Signaling by ERBB4
(inferredTo)	[Pathway:R-HSA-1250342] PI3K events in ERBB4 signaling

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