Reactome | CA4:Zn2+ hydrates CO2 to HCO3-

Schema > Reaction > Entries

CA4:Zn2+ hydrates CO2 to HCO3- Show undefined attributes

catalystActivity	[CatalystActivity:10594205] carbonate dehydratase activity of CA4:Zn2+ [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10594207
displayName	CA4:Zn2+ hydrates CO2 to HCO3-
eventOf	[Pathway:R-DRE-1237044] Erythrocytes take up carbon dioxide and release oxygen - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- - Homo sapiens
input	[SimpleEntity:R-ALL-1237009] CO2 [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	CA4:Zn2+ hydrates CO2 to HCO3- Carbonic anhydrase IV hydrates carbon dioxide to bicarbonate and a proton H2O + CO2 -> H+ + HCO3-
output	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-425425] HCO3- [extracellular region]
precedingEvent	[Reaction:R-DRE-70967] IDH3 complex decarboxylates isocitrate - Danio rerio [Reaction:R-DRE-450984] IDH2 dimer decarboxylates isocitrate - Danio rerio [Reaction:R-DRE-71401] OGDH dimer decarboxylates 2-OG - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1237047
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1237044] Erythrocytes take up carbon dioxide and release oxygen
(inferredTo)	[Reaction:R-HSA-1237047] CA4:Zn2+ hydrates CO2 to HCO3-

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