Reactome | SOS-mediated signalling

Schema > Pathway > Entries

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10647712
displayName	SOS-mediated signalling
eventOf	[Pathway:R-DRE-112399] IRS-mediated signalling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Danio rerio
inferredFrom	[Pathway:R-HSA-112412] SOS-mediated signalling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SOS-mediated signalling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-112412
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-112399] IRS-mediated signalling
(inferredTo)	[Pathway:R-HSA-112412] SOS-mediated signalling

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