Reactome | Activation of caspases through apoptosome-mediated cleavage

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Activation of caspases through apoptosome-mediated cleavage Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648002
displayName	Activation of caspases through apoptosome-mediated cleavage
eventOf	[Pathway:R-DRE-111461] Cytochrome c-mediated apoptotic response - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2133497] apoptotic signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-114252] Cleavage of Procaspase-3 by the apoptosome - Danio rerio [Reaction:R-DRE-114261] Cleavage of Procaspase-7 by the apoptosome - Danio rerio
inferredFrom	[Pathway:R-HSA-111459] Activation of caspases through apoptosome-mediated cleavage - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activation of caspases through apoptosome-mediated cleavage
precedingEvent	[Pathway:R-DRE-111458] Formation of apoptosome - Danio rerio
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-111459
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-111461] Cytochrome c-mediated apoptotic response
(inferredTo)	[Pathway:R-HSA-111459] Activation of caspases through apoptosome-mediated cleavage

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