Reactome | Recognition of DNA damage by PCNA-containing replication complex

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Recognition of DNA damage by PCNA-containing replication complex Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649998
displayName	Recognition of DNA damage by PCNA-containing replication complex
eventOf	[Pathway:R-DRE-73893] DNA Damage Bypass - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:6792104] positive regulation of error-prone translesion synthesis
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-5652005] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA - Danio rerio [Reaction:R-DRE-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Danio rerio [Reaction:R-DRE-5655481] USP1:WDR48 binds monoUb:K164-PCNA - Danio rerio [Reaction:R-DRE-5655466] USP1:WDR48 deubiquitinates monoUb:K164-PCNA - Danio rerio [Reaction:R-DRE-5655483] USP1 autocleavage - Danio rerio
inferredFrom	[Pathway:R-HSA-110314] Recognition of DNA damage by PCNA-containing replication complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Recognition of DNA damage by PCNA-containing replication complex
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-110314
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-73893] DNA Damage Bypass
(inferredTo)	[Pathway:R-HSA-110314] Recognition of DNA damage by PCNA-containing replication complex

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