Reactome | Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP

Schema > Reaction > Entries

Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP Show undefined attributes

catalystActivity	[CatalystActivity:10860341] protein tyrosine phosphatase activity of PTPN2-1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10860343
displayName	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP
eventOf	[Pathway:R-DME-877312] Regulation of IFNG signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-997326] Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-DME-873824] p-STAT1 homodimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP
output	4 × [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-DME-997294] Stat92E [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-DME-873917] Translocation of STAT1 dimer to nucleus - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-997326
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-877312] Regulation of IFNG signaling
(inferredTo)	[Reaction:R-HSA-997326] Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP

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