Reactome | FXIIa activates plasma kallikrein-kinin system

Schema > Pathway > Entries

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911172
displayName	FXIIa activates plasma kallikrein-kinin system
eventOf	[Pathway:R-DME-168249] Innate Immune System - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259393] plasma kallikrein-kinin cascade
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DME-9855719] Regulation of FXIIa and plasma kallikrein activity - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	FXIIa activates plasma kallikrein-kinin system Factor XIIa activates plasma kallikrein-kinin system
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9970672
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-168249] Innate Immune System
(inferredTo)	[Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system

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