Reactome | PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS

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PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS Show undefined attributes

catalystActivity	[CatalystActivity:10910431] poly(A) RNA polymerase activity of Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910433
displayName	PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS
eventOf	[Pathway:R-DME-9770562] mRNA Polyadenylation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9970189] PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS - Homo sapiens
input	250 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-DME-72008] Pabp2 [nucleoplasm] [Complex:R-DME-9970298] Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS
output	250 × [SimpleEntity:R-ALL-113541] PPi [nucleoplasm] [Complex:R-DME-9970319] Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9970189
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9770562] mRNA Polyadenylation
(inferredTo)	[BlackBoxEvent:R-HSA-9970189] PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS

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